Homology modeling of a voltage-gated potassium channel (human Kv7.1)
نویسندگان
چکیده
منابع مشابه
Lipid-dependent gating of a voltage-gated potassium channel
Recent studies hypothesized that phospholipids stabilize two voltage-sensing arginine residues of certain voltage-gated potassium channels in activated conformations. It remains unclear how lipids directly affect these channels. Here, by examining the conformations of the KvAP in different lipids, we showed that without voltage change, the voltage-sensor domains switched from the activated to t...
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متن کاملConstruction and validation of a homology model of the human voltage-gated proton channel hHV1
The topological similarity of voltage-gated proton channels (H(V)1s) to the voltage-sensing domain (VSD) of other voltage-gated ion channels raises the central question of whether H(V)1s have a similar structure. We present the construction and validation of a homology model of the human H(V)1 (hH(V)1). Multiple structural alignment was used to construct structural models of the open (proton-co...
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lung cancer is associated with anti-Hu paraneoplastic LE. Since the report of Fukushima et al. [1] , we have shown the serum of their patient to be strongly positive for VGKC-Ab (2,354 p M ). The antibody titre decreased during treatment to 901 p M . This test is a radioimmunoassay utilising the binding of 125 I-radiolabelled -dendrotoxin to specific potassium channels. The results are expresse...
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ژورنال
عنوان ژورنال: BMC Bioinformatics
سال: 2007
ISSN: 1471-2105
DOI: 10.1186/1471-2105-8-s8-p2